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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Ascorbate
Research Papers that Mention the Interaction
“ Ascorbate (50 and 150 μM) induced a time (max at 2–3 h)‐dependent inhibition of the EDHF‐mediated component of vasodilatation to bradykinin or acetylcholine in perfused segments, but not in rings.”
Requirement for flow in the blockade of endothelium‐derived hyperpolarizing factor (EDHF) by ascorbate in the bovine ciliary artery“ Ascorbate (50 μM) also blocked acetylcholine‐induced , EDHF‐mediated vasodilator responses in the rat mesenteric arterial bed in a time‐dependent manner (maximum blockade at 180 min).”
“In the bovine eye, EDHF‐mediated vasodilator responses induced by acetylcholine or bradykinin were powerfully blocked when ascorbate (50 μM) was included in the perfusion medium for at least 120 min; with acetylcholine a normally‐masked muscarinic vasoconstrictor response was also uncovered.”
“These results suggest that ascorbate promotes acetylcholine release from intramural cholinergic nerves.”
“Exogenous ACh application resulted in the downregulation of the activity of the antioxidant enzymes, ascorbate peroxidase, and catalase.”
Comparative transcriptome analysis reveals the regulatory effects of acetylcholine on salt tolerance of Nicotiana benthamiana.
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