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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Arachidonic Acid
Research Papers that Mention the Interaction
“Since AA is a natural ligand for PPARα, ACh stimulates PPARα probably via AA.”
PPARα induced NOS1 phosphorylation via PI3K/Akt in guinea pig antral mucous cells: NO-enhancement in Ca(2+)-regulated exocytosis.“Thus, ACh stimulates AA accumulation via an [Ca2+]i increase, which activates PPARα, leading to enhancement of Ca2+‐regulated exocytosis in antral mucous cells.”
“ ACh stimulates arachidonic acid (AA) release from membrane phospholipids of vascular endothelial cells (ECs).”
“ Acetylcholine stimulates the release of endothelium-derived arachidonic acid ( AA ) metabolites including prostacyclin and epoxyeicosatrienoic acids (EETs), which relax coronary arteries.”
“The basal release of arachidonic acid was initially increased by infusion of acetylcholine and became lower than the initial basal levels after 30 min of infusion.”
“Since muscarinic activation triggers AA production and we now observed that AA enhances ACh release, it is proposed that AA may act as a facilitatory retrograde messenger in hippocampal cholinergic muscarinic transmission as it has been proposed to act in glutamatergic transmission.”
“These results indicate that arachidonic acid endogenously formed under weak stimulation of NMDA receptors contributes to the regulation of the evoked release of [3H]‐acetylcholine by facilitating GABAergic transmission and that this process is more important in striosomes than in the matrix.”
“Moreover, the neuronal arachidonic acid production evoked by glutamate was potentiated by acetylcholine.”
“ ACh increases [3H]arachidonic acid release in esophageal but not in lower esophageal sphincter (LES) muscle.”
“ Arachidonic acid (10 uM) perfused into an adrenal gland of the rat … caused a significant inhibition of CA secretion evoked by ACh (5.32×10−3 M), DMPP (10−4 M) and muscarine (10−4 M) … did not affect that induced by excess K+ (5.6×10−2 M).”
“The perfusion of arachidonic acid along with indomethacin (30 uM), which is an inhibitor of cyclooxygenase, for 20 min attenuated markedly CA secretory effect evoked by ACh , DMPP and muscarine while it did not influence that by excess K+.”
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