Possible Interaction: Acetylcholine and Amphetamine

“Here we have shown that AMPH enantiomers bind to the &agr;7 nAChR and competitively inhibit acetylcholine responses.”

“In the calcium fluorescence study it was observed that the group treated with amphetamine , fluoxetine or sibutramine showed higher basal Ca(2+) fluorescence after stimulus with KCl (70 mM), noradrenaline (10(-4)M) or acetylcholine (10(-4)M).”

“ Amphetamine produced greater increases in ACh release than in shams, indicating that nVHLX does not impair the capacity of cholinergic neurons to release ACh.”

“Under anaesthesia, amphetamine increased the secretion of salivary fluid and the amount of protein therein in response to acetylcholine.”

“Those agents that decreased cholinergic function, either by blocking the effect of acetylcholine or by preventing its synthesis, augmented the stimulating effect of amphetamine.”

“It appears that AMPH enhances release of ACH and neurotransmitter amino acids through increased NO synthesis and induces neurotoxicity via NO and also by NO‐independent LPO.”

“Moreover, administration of AMPH led to a marked and long‐lasting increase of ACH release.”

“Moreover, amphetamine caused an immediate release of acetylcholine and aspartate and a delayed release of GABA in the nucleus accumbens.”

“ Amphetamine increased ACh levels in the mPFC, induced a decrease in DOPAC and HVA levels, and increased motor activity.”

“The application of amphetamine reduced the release of ACh and abolished the effect of halothane.”

“Systemic administration of amphetamine results in increases in the release of acetylcholine in the cortex.”

“These data suggest that amphetamine increases cortical acetylcholine release via a complex neuronal network rather than simply increasing basal forebrain D1 or D2 receptor activity.”