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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Alpha-Ketoglutarate
Research Papers that Mention the Interaction
“It is supposed that Na alpha-ketoglutarate is a synergist to acetylcholine.”
“The stimulation effect on oxidative phosphorylation is mostly expressed in case of joint injection of Na alpha-ketoglutarate and acetylcholine.”
[EFFect of alpha-ketoglutarate and acetylcholine synergism on energy metabolism in mitochondria].“The reciprocal effect of acetylcholine on alpha-ketoglutarate and succinate oxidation (acceleration and inhibition, respectively) was observed.”
[Mechanism of reciprocal effects of acetylcholine on oxidation of alpha-ketoglutarate and succinate in heart and liver mitochondria. Factors influencing detection of the acetylcholine effect].“ Acetylcholine in doses of 25, 50 and 100 mg per 100 g of the body weight 5, 15 and 30 min after intraperitoneal injection intensifies the rate of phosphorylative respiration at ketoglutarate oxidation and moderately lowers it at succinate oxidation.”
“ Acetylcholine (ACh) administration stimulated KG oxidation and substrate‐level phosphorylation in isolated mitochondria.”
“The specific stimulation of KG oxidation by ACh is related to a decrease of succinate oxidation and is contrary to the specific stimulating effect of adrenaline on succinate oxidation.”
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