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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetylcholine
supplement:
Acetylcysteine
Research Papers that Mention the Interaction
“ Acetylcholine-mediated femoral vasodilation was similarly potentiated by NAC (p = 0.001).”
N-acetylcysteine improves coronary and peripheral vascular function.“ NAC pretreatment significantly reversed the elevated MDA, AChE and the reduced GSH, ChAT and ACh in the Abeta-model mice.”
Protective effect of N-acetyl-l-cysteine on amyloid β-peptide-induced learning and memory deficits in mice“Neither the superoxide dismutase mimetic, tiron nor the thiol-reducing agent N-acetyl-L-cysteine modified the hyperpolarization evoked by 0.1 microM acetylcholine but each produced a partial and significant inhibition of the hyperpolarization induced by 1 microM acetylcholine.”
“Chronic treatment with n‐acetylcysteine (n=8) selectively restored NO‐contribution in total dilatation to ACh.”
“By … with NAC (15 mmol/… by ACh (95.0% +/- 7.9% versus 62.3% +/- 7.6% for control; ACh dose, 1 mumol/L; P < .001) or by A23187, …, NO-mediated vasodilator (91.6% +/- 9.6% versus 68.3% +/- 12.1% for control; A23187 dose, 1 mumol/L; P < .001).”
“Long-term oral administration of N-acetylcysteine did not alter responses to nitroglycerin but completely prevented the defective relaxation to acetylcholine.”
“ NAC augmented the effect of NTG, ACh and SNP in both nontolerant and nitrate-tolerant animals (P < 0.05).”
“It was also demonstrated that endothelium-dependent relaxations to acetylcholine were enhanced by captopril, GSH, MPG and NAC but not by enalaprilat.”
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