Possible Interaction: Acetylcarnitine and Nitric Oxide

“Finally, we demonstrated that the effects of PLC to augment eNOS activity were associated with a net increase in NO release from endothelial cells.”

“NO production following incubation with PLC was abolished in endothelial cells coincubated with L-NAME, PD173955, LY294002, MK-2206 and compound C. In conclusion, PLC , via AMPK/Src-mediated signaling that leads to activation of PI3 kinase and Akt, stimulates eNOS, leading to increased production of NO.”

“Other molecules, such as the dietary supplement glycine propionyl-L-carnitine (GPLC), have also been suggested to increase levels of NO , although the physiological mechanisms remain to be elucidated.”

“Interestingly, treatment of MS patients with acetylcarnitine resulted in decreased CSF levels of NO reactive metabolites and protein nitration, as well as increased content of GSH and GSH/GSSG ratio.”

“Key antioxidant parameters such as SOD, CAT, GSH, GR … (Ψ∆m) were decreased (P < 0.05), while ALCAR pretreatment prevented these effects by significantly inhibiting ROS (P < 0.001), LPO (… < 0.05), TNF-α (P < 0.05), IFN-γ (P < 0.001), NO (P < 0.01) … the above genes.”

“ PLC also increased NO synthesis by enhancing eNOS expression.”

“ Propionyl-L-carnitine increased NO participation in WKY and SHR.”

“BackgroundRecent research has indicated that short term administration of glycine propionyl-L-carnitine (GPLC) significantly elevates levels of nitric oxide metabolites at rest and in response to reactive hyperaemia.”