“Here, we tested whether toxicities of nifedipine , a dihydropyridine CCB used to treat hypertension, can also be mitigated by co‐treatment with ALCAR.”
“In the zebrafish embryos at three different developmental stages, nifedipine induced developmental toxicity with pericardial sac edema in a dose‐dependent manner, which were surprisingly exacerbated with ALCAR co‐treatment.”
“To the best of our knowledge, these studies for the first time show that nifedipine and the dietary supplement ALCAR together induce adverse effects while providing evidence on the therapeutic efficacy of subanesthetic doses of ketamine against nifedipine toxicity in vivo.”