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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Acetylcarnitine
drug:
Nerve Growth Factor
Research Papers that Mention the Interaction
“ ALC acts via several mechanisms, inducing regeneration of injured nerve fibres, reducing oxidative stress, supporting DNA synthesis in mitochondria, and enhancing nerve growth factor concentrations in neurons.”
Overview on Pathophysiology and Newer Approaches to Treatment of Peripheral Neuropathies“The transcriptional profile of gene expression in PC12 cells indicated that ALC , in the presence of NGF , was able to positively modulate NGFI-A expression, a gene relevant in the rescue from tissue-specific toxicity.”
“Supplements such as vitamin D analogues, zinc, vitamin B12, vitamin A and omega 3 fatty acids or herbal medicines and some drugs such as estrogen, glucocorticoids, acetyl-L-carnitine and antipsychotics can affect NGF levels [4, 5], and whether the participants were using these medications should have been stated.”
“Supplementation of ALCAR , on the other hand, up‐regulated NGF and tyrosine kinase A expression along with concomitant increase in ERK1/2 phosphorylation, thus enhancing cell survival.”
Hypoxia‐induced deactivation of NGF‐mediated ERK1/2 signaling in hippocampal cells: Neuroprotection by acetyl‐L‐carnitine“ Acetyl-l-carnitine (ALCAR) is a physiological peptide with roles in mitochondrial bioenergetic function, which may also increase binding of nerve growth factor by sensory neurons.”
“While NGF binding is decreased in rodent CNS after stress exposure, this reduction is prevented by treatment with Acetyl-L-Carnitine (ALCAR), a chemical substance able to prevent some degenerative events associated with aging.”
“In particular, … demonstrated that ALCAR can counteract the age-dependent reduction of several receptors in the … system of rodents, such as the NMDA receptorial system, the Nerve Growth Factor (NGF) receptors, those of glucocorticoids, neurotransmitters and others, thereby enhancing … of synaptic transmission, which is considerably slowed down by ageing.”
“Here we report that treatment … acetyl-l-carnitine ALCAR ), a substance which has been shown to prevent some impairments of the aged CNS in … animals as well as in patients, is able to increase the levels and utilization of nerve growth factor (NGF) in the CNS of old rats.”
“ Acetyl-L-carnitine (ALCAR) prevents some deficits associated with aging in the central nervous system (CNS), such as the aged-related reduction of nerve growth factor ( NGF ) binding.”
“Also, neurite outgrowth elicited in PC12 cells by NGF (100 ng/ml) was greatly augmented by ALCAR pretreatment.”
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