Possible Interaction: Acetylcarnitine and Glutathione

“Additionally, western blot analysis revealed that ALCAR increased the levels of antioxidant proteins, including catalase, superoxide dismutase, glutathione peroxidase, Nrf2, Keap1 and glutathione.”

“Additionally, pretreatment of ALCAR and LA also led to elevated cellular GSH and heat shock protein (HSP) levels compared to untreated control cells.”

“Addition of ALCAR to neurons also led to an elevated cellular GSH and heat shock proteins (HSPs) levels compared with untreated control cells.”

“Administration of ALCAR increases cellular levels of GSH in rat astrocytes.”

“Our results suggest that ALCAR exerts protective effects against Aβ1–42 toxicity and oxidative stress in part by up‐regulating the levels of GSH and HSPs.”

“Administration of ALC for 5 consecutive days resulted in a significant increase in the activities of both superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) and the level of reduced glutathione ( GSH ), in lung and liver tissues which were reduced by radiation treatment.”

“Pretreatment of the isolated heart with propionyl-L-carnitine (10−7M) improved the functional recovery of the myocardium, reduced GSH and GSSG release and attenuated the accumulation of tissue GSSG.”

“Long-term supplementation with acetyl carnitine significantly reduced GSH depletion, particularly in the brain regions of hippocampus, an effect associated with decreased luminescence and HNE formation.”