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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcarnitine
drug:
Dopamine
Research Papers that Mention the Interaction
“ ALCAR attenuated the PTZ induced reduction in [3-(13)C]alanine and the increase in dopamine in the HF.”
Dietary supplementation with acetyl-l-carnitine in seizure treatment of pentylenetetrazole kindled mice“These results indicate that ALCAR , when administered intracerebrally at fairly high concentrations, can affect the level and the release not only of such neurotransmitters as acetylcholine and dopamine , but also of amino acids.”
“Repeated acetyl‐l‐carnitine (ALCAR) administration persistently increases dopamine outflow in the nucleus accumbens.”
“A 7-day administration of ALCAR in rats increased dopamine and serotonin output in the nucleus accumbens shell and it prevented the development of escape deficit produced by acute exposure to unavoidable stress.”
“Moreover, the response of the enzyme to CCh, NE and DA was potentiated by the subchronic administration of ALCAR.”
“Animal studies have … that AL ad ministration persistently increases dop amine ou tflow in the nucleus accumbens.4 Carnitine supplementation has been shown to significantly increase the levels of dopamine in the cortex, hippocampus, and striatum of rat brain.3 Dopamine dysregulation in this pathway has been shown to cause psychotic symptoms.”
Psychosis Precipitated by Acetyl-l-Carnitine in a Patient With Bipolar Disorder.
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