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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Acetylcarnitine
drug:
Cisplatin
Research Papers that Mention the Interaction
“We also found that cisplatin caused an increase in the urinary excretion of carnitine and acetylcarnitine in wild-type mice but not in Oct1/2(−/−) mice, suggesting that tubular transport of cisplatin is a prerequisite for this phenomenon.”
Cisplatin-Induced Downregulation of OCTN2 Affects Carnitine Wasting“Results: ALC enhanced the sensitivity to cisplatin of tumor cells with functional p53.”
“In this study we have tested the hypothesis that ALC may have a protective role on cisplatin and paclitaxel-induced neuropathy.”
“ ALC were effectively inhibited the increase in cisplatin induced oxidized glutathione and lipid peroxidation formation in NB cells.”
“Prophylactic 10 and 50 μmol of ALC concentrations were decreased cisplatin induced lipid peroxidation compared to controls that normally exhibited apoptosis especially in SH-SY5Y cells.”
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