Possible Interaction: Acetylcarnitine and Antioxidants

“Additionally, western blot analysis revealed that ALCAR increased the levels of antioxidant proteins , including catalase, superoxide dismutase, glutathione peroxidase, Nrf2, Keap1 and glutathione.”

“The present results suggested that ALCAR either prevents or ameliorates the actions of the antioxidant system in HLECs at the level of the protein and the gene.”

“We conclude that LA is highly effective in reversing oxidative stress arising from iron overload and that its antioxidant efficacy is further enhanced in combination with ALCAR.”

“Conclusions ALCAR can inhibit the expressions of inflammatory factors and antioxidation to suppress the development of atherosclerosis by adjusting blood lipid in the myocardium of AS rats.”

“ ALC could concentration-dependently counteract the arsenic-induced oxidative stress, modulate the antioxidant defense capacity, and improve mitochondrial functions.”

“… antioxidant parameters such as SOD, CAT, GSH, GR …) were decreased (P < 0.05), while ALCAR pretreatment prevented these effects by significantly inhibiting ROS (P < 0.001), LPO (P < 0.001), Ca2+ (P < ….05), IFN-γ (P < 0.001), NO (P < 0.01) levels and expression of the above genes.”

“In conclusion, data obtained from this study indicate that ALC could increase the endogenous antioxidant defense mechanism in rat and there by protect the animals from radiation-induced organs toxicity.”