Possible Interaction: Acetylcarnitine and Adenosine Triphosphate

“ PLC and ALC produced a significant increase in plasma levels of adenosine and ATP , whereas LC induced less relevant changes.”

“ ATP depletion decreased incorporation of [1-14C]palmitic and/or [9,10-3H]oleic acid into acyl-L-carnitine , but the incorporation into phosphatidylcholine and phosphatidylethanolamine was unaffected.”

“ ALCAR also increased the activity of cytochrome oxidase, which in turn amplified ATP production.”

“Further, ATP production was enhanced along with acetyl-L-carnitine treatments (p≤0.05).”

“We conclude that PLC improves the diastolic function by increasing the fraction of energy available from fatty acid oxidation in the form of ATP.”

“ Propionyl-L-carnitine reduced the ischemic deterioration of mitochondrial function and the depletion of tissue stores of ATP.”

“In addition, ALCAR supplementation partly reduces the leptin resistance that occurs in old rats, and improves ATP production in skeletal muscle mitochondria through an increase in mitochondrial protein content.”

“ Acetyl L‐carnitine (ALCAR), a dietary supplement and an antioxidant, plays a vital role in the bioenergetic process that produces ATP.”

“Here, using zebrafish embryos, we explored whether ALCAR modulated ATP synthesis, generation of reactive oxygen species (ROS) and expression of specific genes related to major signaling pathways that control metabolism, growth, differentiation, apoptosis and oxidative stress.”