Possible Interaction: Acetic Acid and Xylose

“Presence of acetic acid in the fermentation led to significant reduction in the cell growth rate, reduction in xylose consumption and ethanol production rate.”

“In this study, we evaluated the inhibitory effects of acetic acid on glucose and xylose fermentation by a high performance engineered strain of xylose utilizing Saccharomyces cerevisiae, SXA-R2P-E, harboring a xylose isomerase based pathway.”

“In fed‐batch cultures fed with hydrolysate or a model xylose–acetic acid mixture, co‐consumption of xylose and acetic acid was observed, which resulted in a pH increase.”

“This strain exhibited improved cell growth and ethanol production from xylose under aerobic and oxygen limited conditions, respectively, in the presence of acetic acid.”

“Also up‐regulation of HXT1 and TKL1 might enhance xylose consumption in the presence of acetic acid.”

“The inhibitory effect of acetic acid was particularly marked for the consumption rate of xylose , as compared with that of glucose.”

“Glucose- and xylose-specific consumption rates decreased as the acetic acid concentration increased, with the inhibitory effect being more severe for xylose consumption.”

“ Acetic acid produced in xylose fermenting process inhibited ethanol production of XE-1.”

“In contrast, at pH 3.5 acetic acid had a strong and specific negative impact on xylose consumption rates, which, after glucose depletion, slowed down dramatically, leaving 50% of the xylose unused after 48 h of fermentation.”

“The inhibitory action of acetic acid on growth, on glucose consumption and on all product formation rates was found to be significant (p < or = 0.05), as well as formic acid inhibition on xylose consumption and biomass production.”