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“ Tizanidine strongly inhibited the writhing response induced by acetic acid , phenyl-p-benzoquinone and acetylcholine in mice, and its potency was found to be greater than that of morphine.”
Naunyn-Schmiedeberg's Archives of Pharmacology • 2004 | View Paper
“ Tizanidine (0.25-1.0 mg/kg) significantly produced analgesic and anti-inflammatory effect in acetic acid induced writhing in mice and carrageenan-induced paw edema in rats, respectively.”