“In conclusion, TNB and acetic acid induced colitis can be pharmacologically manipulated by TEMPOL.”
“Intragastric administration of TEMPOL , 0.5 g/kg/bw, immediately after intracaecal administration of 5% acetic acid significantly decreased mucosal lesion area, myeloperoxidase activity, and leukotriene B4 and C4 generation when assessed 24 hours after damage induction.”