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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Acetic Acid and Probenecid

supplement:

Acetic Acid

drug:

Probenecid

Research Papers that Mention the Interaction

“Application of probenecid , which blocks the efflux of 5-hydroxyindole acetic acid from the brain, led to an augmented accumulation of this serotonin metabolite in the affected males.”
Increase of Tryptophan and 5-Hydroxyindole Acetic Acid in the Brain of Ornithine Carbamoyltransferase Deficient Sparse-Fur Mice
Pediatric Research  •  1984  |  View Paper
“Furthermore, we have reason to believe that it is possible to block almost completely the active out transport of 5-hydroxyindole acetic acid from the cerebrospinal fluid by high doses of probenecid given intravenously or intrathecally.”
5-Hydroxyindole acetic acid and homovanillic acid in cerebrospinal fluid after intrathecal and intravenous administration of probenecid to normal and hydrocephalic dogs.
Acta pharmacologica et toxicologica  •  1973  |  View Paper