Possible Interaction: Acetic Acid and Indomethacin

“ Indomethacin significantly delays the healing of acetic acid ulcers, probably by reducing endogenous prostaglandins and inhibiting angiogenesis in ulcerated tissue.”

“ Indomethacin reduced, and capsaicin pretreatment almost completely abolished, both pain behavior and bladder overactivity induced by acetic acid injection.”

“The healing of acetic acid ulcers was delayed by the daily subcutaneous administration of indomethacin (1 mg/kg) for two or four weeks after ulceration.”

“Mice submitted to the writhing test using acetic acid presented 58% and 56% of inhibition in writhes with EOCS and indomethacin , respectively.”

“We previously discovered that a 4-wk course of indomethacin delivered to rats with acetic acid ulcers resulted in production of "unhealed gastric ulcers" that persisted for up to 12 wks after treatment cessation.”

“Both indomethacin and NS398 reversed the MPO activity reduction induced by 1% AA pretreatment.”

“ Indomethacin abolished the gross mucosal protective effect by 1% AA pretreatment in 8% AA-derived colitis in normal rats while the NS398 had no effect.”

“Four-week treatment with indomethacin significantly delayed the healing of acetic acid ulcers.”

“Finally, despite being able to potentiate the analgesic effect of indomethacin in mouse writhing caused by acetic acid , the pretreatment with the polar fraction (200 mg/kg, oral) significantly prevented indomethacin-induced ulcers in rats.(ABSTRACT TRUNCATED AT 250 WORDS)”

“Repeated administration of indomethacin or prednisolone for 2 weeks apparently delayed the healing of initial gastric ulcers induced by acetic acid injection in rats.”

“Gastric mucosal prostaglandin E2 levels in rats with ulcers (5 days after acetic acid injection ) were also markedly reduced by indomethacin.”