Possible Interaction: Acetic Acid and Atropine

“When the colonic balloon was filled with a subthreshold volume (0.5 ml), the intraluminal instillation of acetic acid triggered a high‐amplitude phasic colonic motility which was partially reduced by nepadutant and suppressed by either hexamethonium or atropine.”

“Oral administration of Styrax camporum Pohl and Caesalpinia ferrea Martius stem extracts, atropine , and cimetidine, during 15 days, decreased the ulceration size, gastric secretion volume, and increased collagen fibre number of chronic ulcer induced by acetic acid in rats.”

“ Atropine treatment significantly inhibited pancreatic flow rate and protein output after acetic acid perfusion, but no inhibition of flow rate and a slight decrease in the protein output after lactic acid perfusion were seen.”

“With respect to plasma peptide concentrations, significant increases in secretin and VIP levels were found after perfusion of both organic acids; atropine administration significantly decreased plasma secretin levels after acetic acid administration although it did not affect plasma VIP concentrations.”

“ HOAcE was antagonized noncompetively by 1(1-naphthyl) piperazine (1-NP) and cyproheptadine and antagonized competitively by atropine (ATR).”

“A H2-agonist and atropine were less effective and propranolol, phentolamine and imidazole acetic acid had little effect.”