Possible Interaction: Acetic Acid and Aspirin

“In this case, the skin burn is due to combination therapy of acetic acid and acetylsalicylic acid (aspirin) – a mixture of two different acids, the concentration of which is not exactly known.”

“This is a very interesting observation showing that an application of a combination of acetic acid and acetylsalicylic acid can cause a split-thickness chemical burn.”

“… acetic acid … acetylsalicylic acid is toxic to skin, it is our personal experience that acetic acid alone is non-toxic to skin as well as to open … is a shortage of therapeutic options, especially in skin and soft tissue including burn infections caused by multiple antibiotic-resistant P. aeruginosa.”

“Administration of 2.5 mg l−1 aspirin , 5 mg l−1 lidocaine and 48 mg l−1 morphine prevented the behavioural changes induced by acetic acid.”

“The extract and the standard drug Aspirin ) significantly decreased the number of writhes caused by acetic acid at p<0.001.”

“The results of the morphological evaluation showed that on day 1 acetic acid produced significantly more necrosis in the groups treated with AE (10% and 20%) or 5‐ASA than the controls.”

“Distribution of Asp and its metabolites into the hippocampus, striatum and hypothalamus were increased by treatment with Con A. Asp esterase activities … by pretreatment with Con A, but these enzyme activities were decreased by a high dose of Con A. The inhibitory effect of Asp, … acetic acid in … control.”