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Toxicology and applied pharmacology • 1997 | View Paper
“ Acetic acid is inhibitory to the growth of the yeast Saccharomyces cerevisiae, causing ATP starvation and oxidative stress, which leads to the suboptimal production of fuels and chemicals from lignocellulosic biomass.”
“ Intracellular adenosine triphosphate (ATP) levels were severely decreased upon acetic acid treatment, which likely slowed ATP-dependent proton symport, the major form of transport in yeast for nutrients other than glucose.”
“The ATP yield decreased from approximately 14 to 4 g biomass (mol ATP)(-1) when the concentration of acetic acid increased from 0 to 170 mM. Intracellular acidification was much weaker than previously reported for non-adapted cells.”