Possible Interaction: Acetazolamide and Sodium Bicarbonate

“Similarly, carbonic anhydrase inhibitors, such as acetazolamide , reduce the reabsorption of NaCl and NaHCO3 in the same proportion as a rise in plasma pH, and abolish GTB.”

“Good linear correlations were found between the effects of acetazolamide and NaHCO3 on urinePco2 (r=0.878,P<0.001), and on (U-B)Pco2 (r=0.795,P<0.01).”

“In the third test, the metabolic acidosis caused by acetazolamide was reduced by the injection of sodium bicarbonate , and a stronger effect than in the first test was observed.”

“To examine if a fraction of this absorption is passive, NaHCO3 absorption and associated NaCl absorption in proximal tubules were inhibited by acetazolamide , a carbonic anhydrase inhibitor.”

“Intravenous infusion of NaHCO3 (0.5 M) also significantly prevented the lesion with a concomitant suppression of the PD reduction in response to hemorrhagic shock, but these effects were significantly reversed by pretreatment of the animals with acetazolamide (50 mg/kg).”

“It was found that: … isotonic reabsorption; 2) acetazolamide , at either … in the bicarbonate-containing solution , but the same level of inhibition was attained when the inhibitor was tested in the glycodiazine-buffered … resembled that of acetazolamide except that, in either buffer, furosemide was a less potent inhibitor of reabsorption.”