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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetazolamide
supplement:
Secretin
Research Papers that Mention the Interaction
“The effect of secretin was partially inhibited by prior infusions of the carbonic anhydrase inhibitor, acetazolamide.”
Effect of secretin and acetazolamide on the volume and electrolyte composition of hepatic bile in man.“Summary Intravenous injection of 2-acetylamino −1,3,4 - thiadiazole-5-sulfonamide (compound No. 6063) in pancreatic fistula dogs results in a marked reduction in the volume output and the bicarbonate concentration of pancreatic secretion following stimulation with secretin.”
“ Acetazolamide reduced bile HCO3- secretion in six secretin infused, bile-acid depleted pigs by 67 (58-71)% at arterial pH 7.41 (7.38-7.46).”
Importance of carbonic anhydrase for canalicular and ductular choleresis in the pig.“In unanesthetized dogs with chronic gastric and pancreatic fistulas, an intravenous infusion of acetazolamide (Diamox), superimposed on a steady-state infusion of secretin , caused a prompt reduction in the volume and bicarbonate concentration of pancreatic secretion and a delayed reduction in potassium concentration.”
“ Acetazolamide slightly augmented the bile flow but reduced the fiow response of the pancreas to secretin.”
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