supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Acetazolamide
supplement:
Glucose
Research Papers that Mention the Interaction
“ Acetazolamide (5.0 mM) did not affect the activity of volume-sensitive anion channels in beta-cells but lowered intracellular pH and adversely affected both the bioelectrical response to d-glucose and its effect on the cytosolic concentration of Ca2+ in these cells.”
Possible role of carbonic anhydrase in rat pancreatic islets: enzymatic, secretory, metabolic, ionic, and electrical aspects.“ ACZ inhibited NH3 (14.2 … 0.01) and glucose (1.6 to 1.2 mumol/min/gm, p less than 0.05) and stimulated glutamate (2.2 to 2.….01) production by isolated tubules from normal rats incubated with 2 mM glutamine and had similar effects with acidotic animals.”
“ Acetazolamide , on the other hand, was more effective in inhibiting oxygen uptake in the presence of glucose than in the presence of glutamic acid.”
“Administration of acetazolamide , 20 mg (90 μmol)/kg, in nine dogs significantly reduced proximal tubular reabsorption of sodium and glucose and slightly increased ‘distal’ delivery of glucose.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback