Possible Interaction: Acetazolamide and Calcium Supplement

“The observed changes in calcium and phosphate metabolism may be secondary to the renal effect of acetazolamide.”

“Abstract Aminobenzolamide 5-sulfanilylamido-1,3,4-thiadiazole-2-sulfonamide ) is a potent inhibitor of the zinc enzyme carbonic anhydrase ( CA , EC 4.2.1.1), being at the same time structurally similar to the antimicrobial sulfonamides.”

“As a proof of concept for an intervention strategy with small molecules, we showed that binding of the CA inhibitor acetazolamide increases the stability of the native state of the mutant by 2.9kcal/mol in accordance with its strong affinity.”

“The administration of acetazolamide was shown to increase the excretion of calcium in both normal persons and in stone formers, while at the same time the urinary excretion of citrate was reduced.”

“25 In rats, acetazolamide administration has been observed to result in the deposition of calcium ”

“The inhibition of CA by acetazolamide and suppression of CgCA gene via RNA interference could increase the intracellular Ca2+ in hemocytes (p<0.05).”

“It was observed that CA from the sturgeon gill in the presence of the sulfanilamide and acetazolamide as an inhibitor had very low IC50 values such as 13.0 and 0.1 μM, respectively.”

“ Acetazolamide treatment in vivo inhibited about 50% of the calcium uptake during both pre-exuvial secretion and postexuvial reabsorption.”

“The injection of 10 mg of acetazolamide into fertile chicken eggs on the 16th or 17th day of incubation resulted in a decreased accumulation of calcium by the developing embryo.”

“ Acetazolamide (… Ca++ by 41%, but (TF/P)(K+) fell from 1.03+/-0.03 to 0.89+/-0.04 (P < 0.005) so that FR of … separate uphill transport system for K+ in proximal tubules is therefore unmasked by acetazolamide, a drug which selectively inhibits Na+ (and Ca++) reabsorption.”