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Last Updated: 2 years ago

Possible Interaction: Acetazolamide and Caffeine

supplement:

Caffeine

Research Papers that Mention the Interaction

For a variety of pharmaceutical agents acetazolamide , mitomycin C, hydroxyurea, 5-fluorouracil), caffeine was shown to enhance the teratogenic effect of the agent.
Regulatory toxicology and pharmacology : RTP  •  1994  |  View Paper
The increase in fetal malformations seen, especially right forelimb electrodactyly, was augmented at both dose levels of acetazolamide by concomitant exposure to caffeine.
This study provides evidence that a subteratogenic dose of caffeine can potentiate the teratogenic effect of acetazolamide in C57BL/6J mice when dams are treated on day 9 of gestation.
Teratology  •  1991  |  View Paper
This study provides evidence that ACZM , coupled with a subteratogenic dose of caffeine can produce abnormalities in the "resistant" SWV mice, using the endpoint of exencephaly on day 8 of gestation.
Reproductive toxicology  •  1993  |  View Paper