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Last Updated: 2 years ago

Possible Interaction: Acetaminophen and Vitamin E

supplement:

Vitamin E

Research Papers that Mention the Interaction

APAP administration induces hepatotoxicity, lipid peroxidation, and glutathione (GSH) depletion, and these were markedly suppressed by the ferroptosis-specific inhibitor Ferrostatin-1 (Fer-1), the iron chelator deferoxamine, and α-tocopherol ( vitamin E ), indicating that ferroptosis in hepatocytes contributes to the development of APAP-induced hepatotoxicity.
Archives of Toxicology  •  2020  |  View Paper
However, ginger or vitamin E treatment prior to APAP showed significant hepatoprotective effect by lowering the hepatic marker enzymes (AST, ALT, ALP, and arginase) and total bilirubin in plasma.
Journal of dietary supplements  •  2013  |  View Paper
These results suggest that oxidative stress followed by lipid peroxidation might play a role in the pathogenesis of APAP-induced hepatic injury, and pretreatment with lipid-soluble antioxidants such as CoQ10 and alpha-Toc can limit hepatic injury produced by APAP.
Free radical biology & medicine  •  1995  |  View Paper
However, no change was observed in the activity of glutathione reductase (GR) after acetaminophen treatment, while acetaminophen plus vitamin E treated rats showed significant increase in GR activity.
Indian journal of experimental biology  •  1995  |  View Paper
In methionine-supplemented animals, the addition of either selenium or vitamin E increased the LD50 of acetaminophen to 167 and 200 mg/kg, respectively.
Vitamin E and selenium deficiencies led to an increase in the acute lethality of acetaminophen , with a decrease in the LD50 from 376 to 84 mg/kg.
The Journal of nutrition  •  1992  |  View Paper