Possible Interaction: Acetaminophen and Vitamin E

“ APAP administration induces hepatotoxicity, lipid peroxidation, and glutathione (GSH) depletion, and these were markedly suppressed by the ferroptosis-specific inhibitor Ferrostatin-1 (Fer-1), the iron chelator deferoxamine, and α-tocopherol ( vitamin E ), indicating that ferroptosis in hepatocytes contributes to the development of APAP-induced hepatotoxicity.”

“However, ginger or vitamin E treatment prior to APAP showed significant hepatoprotective effect by lowering the hepatic marker enzymes (AST, ALT, ALP, and arginase) and total bilirubin in plasma.”

“These results suggest that oxidative stress followed by lipid peroxidation might play a role in the pathogenesis of APAP-induced hepatic injury, and pretreatment with lipid-soluble antioxidants such as CoQ10 and alpha-Toc can limit hepatic injury produced by APAP.”

“However, no change was observed in the activity of glutathione reductase (GR) after acetaminophen treatment, while acetaminophen plus vitamin E treated rats showed significant increase in GR activity.”

“In methionine-supplemented animals, the addition of either selenium or vitamin E increased the LD50 of acetaminophen to 167 and 200 mg/kg, respectively.”

“ Vitamin E and selenium deficiencies led to an increase in the acute lethality of acetaminophen , with a decrease in the LD50 from 376 to 84 mg/kg.”