Possible Interaction: Acetaminophen and Vitamin C

“ Asc prominently mitigated APAP toxicity in KO mice irrespective of the iron status but had no effect on the synergistic action of iron and APAP in the WT mice, suggesting that the mechanism for the deteriorating action of loaded iron is different from that of APAP toxicity.”

“… PC … ascorbic acid (AA), also in a dose of 3 X 1000 mg, a decreased level of UDS was observed after 24, 72 and 168 h ….20 +/- 0.05% at 0 h AA did not decrease the genotoxic effect of PC, but prolonged the influence of PC on UDS.”

“The LPO level was increased 72 h after the simultaneous application of PC and AA (1.26 nmole MDA/ml).”

“… PC … ascorbic acid (AA), also in a dose of 3 x 1000 mg, an increased frequency of AB.C. was observed only after 72 h, of … in LPO as determined by the thiobarbituric acid assay was seen after PC administration (1.02-1.10 nmole malondialdehyde (MDA)/ml plasma).”

“ Acetaminophen treatment significantly depleted hepatic GSH and ascorbic acid levels , increased hepatic level of malonyldialdehyde (MDA), reactive oxygen species (ROS), and oxidized glutathione (GSSG), as well as decreased hepatic activity of glutathione peroxidase (GPX), catalase, and superoxide dismutase (SOD) (P < 0.05).”

“6,7 Besides, pretreatment with vitamin C has been shown to be protective against APAP induced hepatotoxicity in animals.”

“ Ascorbinic acid being administered in combination with PC and ASA had no influence on MDA formation but significantly weakened CL intensity when subtoxic doses of indicated drugs were used.”

“ Ascorbic acid , 1 g/kg, given to mice 1 hour before and 1 hour after either acetaminophen or cocaine treatment prevented development of the severe hepatocellular damage observed with administration of either drug alone.”

“However, ascorbic acid treatment alone produced a modest decrease in hepatic glutathione content and did not prevent marked hepatic glutathione depletion when administered concomitantly with acetaminophen.”

“Plasma disappearance of acetaminophen was less rapid in ascorbic acid-treated animals, suggesting that in vivo metabolism of acetaminophen was altered by ascorbic acid treatment.”

“The results indicate that ascorbic acid in certain biopharmaceutical forms may have potential use in the development of a safer dosage form of APAP.”

“Glutathione, ascorbic acid , and ethoxyquin inhibited protein covalent binding of acetaminophen arising from both pathways.”

“Adding ascorbic acid to incubations containing acetaminophen and cysteine markedly decreased acetaminophen-cysteine adduct formation.”

“Adding ascorbic acid to microsomal incubations containing acetaminophen inhibited covalent binding of the reactive metabolite.”