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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetaminophen
supplement:
Ubiquinone
Research Papers that Mention the Interaction
“Moreover, CoQ10 treatment decreased the ROS levels and promoted the antioxidative related gene expression in APAP overdose mice.”
“Treatment of CoQ10 significantly improved the liver injury induced by APAP.”
CoQ10 protects against acetaminophen-induced liver injury by enhancing mitophagy.“ Coenzyme Q10 significantly reduced the levels of serum aminotransferases, suppressed lipid peroxidation, prevented the decreases of reduced glutathione and catalase activity, decreased the elevations of … necrosis factor-α and nitric oxide as well as attenuating the reductions of selenium and zinc ions in liver tissue resulting from acetaminophen administration.”
“The potential protective effect of coenzyme Q10 against acute liver injury induced by a single dose of acetaminophen (700 mg/kg, p.o.)”
“These results suggest that oxidative stress followed by lipid peroxidation might play a role in the pathogenesis of APAP-induced hepatic injury, and pretreatment with lipid-soluble antioxidants such as CoQ10 and alpha-Toc can limit hepatic injury produced by APAP.”
“Moreover, it was revealed that CoQ10 through its antioxidant, anti-inflammatory, and antiapoptotic effects could have a role in improvement of acetaminophen induced toxicity.”
The Effect of Co-Enzyme Q10 on Acute Liver Damage in Rats, a Biochemical and Pathological Study
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