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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetaminophen
supplement:
Tyrosine
Research Papers that Mention the Interaction
“A tryptophan auxotrophic strain trp1Δ was more sensitive to APAP than wild-type and addition of tryptophan completely restored the growth restriction of trp1∆ upon APAP exposure, while tyrosine had an additive effect on APAP toxicity.”
Acetaminophen reduces the protein levels of high affinity amino acid permeases and causes tryptophan depletion“Furthermore, co-exposure of cells to both APAP and tyrosine showed an enhancement of the cellular growth inhibition, suggesting that APAP and tyrosine have a similar mode of action.”
Drug toxicity profiling of a Saccharomyces cerevisiae deubiquitinase deletion panel shows that acetaminophen mimics tyrosine.“Finally, the amino acid tyrosine has been found to be inhibitory in micromolar amounts, similar to acetaminophen.”
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