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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetaminophen
supplement:
Tangeretin
Research Papers that Mention the Interaction
“With human liver microsomal samples that had high P450 3A4 activity, APAP oxidation was stimulated 1.6- to 3.0-fold by tangeretin , nobiletin, and flavone, but inhibited 40-60% by myricetin and quercetin.”
“With rat liver microsomes, APAP oxidation was stimulated 2- to 4-fold by 50 microM flavone or tangeretin and inhibited 65% by myricetin or quercetin.”
Effects of flavonoids on cytochrome P450-dependent acetaminophen metabolism in rats and human liver microsomes.
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