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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetaminophen
supplement:
Selenium
Research Papers that Mention the Interaction
“ Se and non-Se glutathione peroxidase activities were decreased by 40% and 53% respectively, 15 min after acetaminophen administration.”
Oxidative stress by acute acetaminophen administration in mouse liver.“In methionine-supplemented animals, the addition of either selenium or vitamin E increased the LD50 of acetaminophen to 167 and 200 mg/kg, respectively.”
“Vitamin E and selenium deficiencies led to an increase in the acute lethality of acetaminophen , with a decrease in the LD50 from 376 to 84 mg/kg.”
“ Selenium pretreatment decreased … binding of acetaminophen metabolites to hepatic protein, but did not alter hepatic microsomal cytochrome P-450 content or NADPH cytochrome c reductase activity, suggesting that … significantly alter the metabolism of acetaminophen to reactive electrophilic metabolites by the cytochrome P-450-dependent mixed-function oxidase enzyme system.”
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