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Last Updated: 3 years ago

Possible Interaction: Acetaminophen and S-Adenosylmethionine

Research Papers that Mention the Interaction

SAMe further reduced the extent of APAP mediated 4-HNE adduction of CPS-1.
Toxicology and applied pharmacology  •  2014  |  View Paper
SAMe greatly reduced markers of oxidative stress and cytochrome C leakage following APAP overdose.
SAMe significantly increased SOD, GPx, and glutathione reductase activity at 4 h following APAP overdose.
The current study identifies a plausible mechanism for the decreased oxidative stress observed when SAMe is given following APAP.
Toxicology letters  •  2012  |  View Paper
APAP depressed mitochondrial SAMe levels at 4 and 6h relative to the Veh group.
In the nucleus, levels of SAMe were depressed below detectable limits 4h following APAP administration.
This study tested the hypothesis that total hepatic and subcellular SAMe levels are decreased by APAP toxicity.
Total liver SAMe levels were depressed at 4h by APAP overdose, but not at 2 or 6h.
Toxicology and applied pharmacology  •  2010  |  View Paper
In summary, SAMe was protective when given 1h after APAP and was comparable to NAC.
Toxicology  •  2008  |  View Paper
In summary, SAMe reduced APAP toxicity and was more potent than NAC in reducing APAP hepatotoxicity.
The naturally occurring substance S-adenosyl-l-methionine (SAMe) has been reported to reduce the hepatic toxicity of APAP.
Journal of Pharmacology and Experimental Therapeutics  •  2007  |  View Paper
Comparison of groups showed that SAMe reduced APAP toxicity.
Consistent with the SAMe protection of APAP hepatic toxicity, the expected depletion of hepatic glutathione (GSH) levels by APAP was prevented by SAMe pretreatment.
Histological examination also showed that SAMe produced a marked protection in APAP mediated centrilobular necrosis at 4 h after APAP injection.
SAMe pretreatment prevented APAP associated depletion in hepatic glutathione and induction of lipid peroxidation as part of its mechanism of protection.
Toxicology letters  •  2004  |  View Paper
APAP administration induced significant decreases in both hepatic and blood SAMe concentrations.
Pharmacology  •  2004  |  View Paper