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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Acetaminophen and Resveratrol

drug:

Acetaminophen

supplement:

Resveratrol

Research Papers that Mention the Interaction

“Treatment with RES resulted in significant inhibition of CYP2E1, CYP3A11, and CYP1A2 activities, and then caused significant inhibition of the bioactivation of APAP into toxic metabolite NAPQI.”
Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways.
Toxicology letters  •  2015  |  View Paper
“However, RSV decreased protein nitration after APAP treatment, possibly through direct scavenging of peroxynitrite.”
“Our results confirmed that RSV reduced liver injury after APAP overdose in mice.”
Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2015  |  View Paper