Possible Interaction: Acetaminophen and Quercetin

“Additionally, the phytochemicals quercetin , gallic acid, corilagin and ellagic acid are also reported to protect against the cytotoxic effects of paracetamol , microcystins, galactosamine and lipopolysaccharide.”

“With human P450 1A2 expressed in Hep G2 cells, APAP oxidation was inhibited completely by flavone or quercetin.”

“ Quercetin prevented the cytotoxicity induced by a variety of hepatotoxicants including clivorine (Cliv), acetaminophen (APAP), ethanol, carbon tetrachloride (CCl4), and toosendanin (TSN) in human normal liver L-02 cells.”

“ Quercetin inhibited the sulfation of dopamine, (-)-salbutamol, minoxidil and paracetamol and the IC50 values were 1 - 2 orders of magnitude greater in human duodenum than in the liver.”

“… quercetin … acetaminophen and minoxidil by human liver cytosol, partially purified P-form phenolsulfotransferase (PST), and recombinant P-form PST, with IC50 values of 0.025-0.…-mediated sulfation, with IC50 values < 1 microM. Studies of structural analogs indicated the flavonoid 7-hydroxyl group as particularly important for potent inhibition.”

“In non-everted rat gut sac method, the absorption of paracetamol was increased by presence of P-gp inhibitors (verapamil, quinidine and ketoconazole), quercetin and chrysin (50 μg/mL).”

“The maximum plasma concentration (Cmax) and area under the curve (AUC0–12) of paracetamol was significantly increased by quercetin and chrysin co-administration in SDS and MDS.”