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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Acetaminophen
supplement:
Phenethyl Isothiocyanate
Research Papers that Mention the Interaction
“In mouse, PEITC (100 and 200 mg/kg, 3 days) decreased the lethality and hepatotoxicity caused by AA.”
Effects of phenethylisothiocyanate on the expression of glutathione S-transferases and hepatotoxicity induced by acetaminophen“In microsomal incubations, PEITC effectively inhibited the rate of APAP-glutathione formation from APAP as well as the P450 2E1-dependent N-nitrosodimethylamine demethylase and the P450 1A2-dependent ethoxyresorufin O-deethylase activities.”
“The protective action of PEITC against APAP toxicity is attributed to the blocking of APAP activation through inhibition of P450 enzymes.”
“When PEITC (19-150 micromol/kg) was given to mice intragastrically 1 hr before or immediately prior to a toxic dose of APAP , the APAP-induced hepatotoxicity was significantly decreased or was completely prevented.”
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