Possible Interaction: Acetaminophen and Iron, Dietary

“Treatment with FE resulted in inhibition of CYP2E1 activity involved in the transformation of APAP in vivo.”

“ Acetaminophen and NMGDTC, or combinations thereof, reduced cardiac and hepatic excess iron content as measured by inductively coupled plasma atomic emission spectrometry (ICP-AES).”

“ Iron ions play a major role in lipid peroxidation, which is a effect of several agents including acetaminophen (APAP)[I].”

“ Acetaminophen challenge (300 mg/kg, i.p) for 7 days caused significant (P < .01) increases in the levels of bilirubin, liver enzymes, TBARS, and iron , while catalase activity and total protein level were reduced significantly (P < .01).”

“The metabolites of the heme oxygenase pathway, biliverdin, carbon monoxide, and iron may modulate acetaminophen toxicity.”

“BACKGROUND Recent data indicate that iron ions play a major role in lipid peroxidation, a hepatotoxic effect of acetaminophen (APAP).”

“On the other hand, simultaneous treatment with iron was shown to potentiate the prooxidative action of acetaminophen (Younes et al 1986), adriamycin (Muliawan et al 1986), CC14 (Muliawan and Kappus 1983), and ethanol (Nordmann et al 1987).”

“Moreover, higher concentration of dissolved oxygen (DO) facilitated Fe3+ regeneration on clay surfaces and more reactive Fe species distributed in lower pH, which could significantly enhance the removal of AP both in dark and light.”