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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetaminophen
supplement:
Green Tea Extract
Research Papers that Mention the Interaction
“These results highlight that administration of therapeutic doses of GTE induces hepatotoxicity, and imply that in a situation of clinical paracetamol overdose, administration of GTE is likely to potentiate APAP-induced hepatotoxicity.”
Therapeutic dose of green tea extract provokes liver damage and exacerbates paracetamol-induced hepatotoxicity in rats through oxidative stress and caspase 3-dependent apoptosis.“Dose dependent decreases in histopathology scores and serum transaminases were noted when GTE was administered prior to APAP ; whereas, the opposite occurred when GTE was administered after APAP.”
“Similarly, metabolites altered by APAP alone were less changed when GTE was given prior to APAP.”
“These studies demonstrate the complex interaction between GTE and APAP and the need to employ novel analytical strategies to understand the effects of dietary supplements on pharmaceutical compounds.”
“ GrTP supplementation normalized APAP induced Cox-2 expression and Bcl-2 activation (P < 0.01), as evidenced by immunohistochemistry and Western blot analyses.”
“Interactions between green tea polyphenols and APAP have impact on antioxidant capacity of green tea.”
Investigation of antioxidant interaction between Green tea polyphenols and acetaminophen using isobolographic analysis
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