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Last Updated: 2 years ago

Possible Interaction: Acetaminophen and Glutathione



Research Papers that Mention the Interaction

High levels of paracetamol can deplete intracellular GSH.
Melanoma research  •  2003  |  View Paper
HIV-infected patients are, however, advised to avoid substances, such as acetaminophen and other pain relievers, that inherently lower glutathione levels.
AIDS treatment news  •  1997  |  View Paper
acetaminophen , there is potential for … and depletion of glutathione , which may result in mitochondrial dysfunction and DNA damage, but only at doses that result in cell death - thus making … to induce the kind of stable, genetic damage in the nucleus indicative of a genotoxic or carcinogenic hazard in humans.
Regulatory toxicology and pharmacology : RTP  •  2020  |  View Paper
In LO2 cells, APAP exposure decreased the cell viability and glutathione (GSH) content, which were both greatly restored by FMN pretreatment.
PloS one  •  2017  |  View Paper
In all mice hepatic glutathione levels decreased after APAP injection, but they recovered more quickly in M1R-deficient mice.
Free radical biology & medicine  •  2015  |  View Paper
Acetaminophen reduced glutathione and enhanced chemotherapy efficacy in hepatic cancer treatment.
In vivo, acetaminophen was uniformly distributed in tissues and significantly reduced hepatic glutathione.
Anticancer research  •  2013  |  View Paper
By itself, APAP increased MDA formation and had a significant lowering influence on the levels of GSH and GSSG, the GSH/GSSH ratio, and the activities of GR, GST and GCS both in the plasma and liver.
Journal of Biomedical Science  •  2010  |  View Paper
AA and GSH were effective in preventing APAP induced melanoma cell toxicity.
APAP caused time and dose-dependent decline in intracellular GSH content in SK-MEL-28, which preceded cell toxicity.
Journal of pharmaceutical sciences  •  2009  |  View Paper
The potency of acetaminophen against both purified ovine cyclooxygenase-1 (oCOX-1) and human cyclooxygenase-2 (hCOX-2) was increased approximately 30-fold by the presence of glutathione peroxidase and glutathione to give IC50 values of 33 microM and 980 microM, respectively.
Archives of biochemistry and biophysics  •  2001  |  View Paper
Administration … glutathione glycoside (GSH-glyc), a compound newly synthesized … our laboratory, 2 h after acetaminophen injection prevented changes in the GSH and MDA preserving their levels nearly to those of controls; in addition, histological evidence of hepatocyte necrosis was either abolished or severely reduced in the majority of animals.
Experimental and molecular pathology  •  1998  |  View Paper
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