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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetaminophen
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“In contrast, 0.2% CA supplementation in the diet resulted in a moderate delay in progression of liver injury and significantly higher liver regeneration after APAP treatment.”
Role of bile acids in liver injury and regeneration following acetaminophen overdose.“Several hepatotoxic agents with varied chemical mechanisms of toxicity acetaminophen , diquat, and CCl4) depress membrane calcium pumps and/or enhance the permeability of membranes to calcium.”
“ Acetaminophen also induced alterations in mitochondrial calcium levels and decreased the ability of isolated mitochondria to sequester calcium.”
“ Acetaminophen produced a dose-related accumulation of calcium at 4 hr but this increase was highly variable when expressed relative to liver protein content.”
“This allowed potentially toxic elevations in calcium concentration to be detected as early as 2 hr after acetaminophen overdose.”
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