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Last Updated: 4 months ago

Possible Interaction: Acetaminophen and Caffeine



Research Papers that Mention the Interaction

The ability of caffeine to both enhance and accelerate analgesic effects has been documented with a variety of different medications (ie, aspirin, acetaminophen , ibuprofen, and ergotamine).
Headache  •  2004  |  View Paper
Caffeine caused a highly significant (p < 0.01) increase in AUC and AUMC, a significant (p < 0.05) increase in Cmax, and a significant (p < 0.05) decrease in clearance (C1/F) of acetaminophen.
We conclude that caffeine taken in doses commonly available commercially or in a cup of coffee can significantly potentiate the therapeutic potential of acetaminophen in man.
Biopharmaceutics & drug disposition  •  1995  |  View Paper
Recent studies have demonstrated that caffeine acts as an analgesic adjuvant when combined with acetaminophen , aspirin, or their mixture.
Clinical pharmacology and therapeutics  •  1991  |  View Paper
We conclude that caffeine enhances the analgesic efficacy of acetaminophen.
Clinical pharmacology and therapeutics  •  1983  |  View Paper
Compared with analgesic medication alone, combinations of caffeine with analgesic medications, including acetaminophen , acetylsalicylic acid, and ibuprofen, showed significantly improved efficacy in the treatment of patients with TTH or migraine, with favorable tolerability in the vast majority of patients.
The Journal of Headache and Pain  •  2017  |  View Paper
Analgesic effects of acetaminophen and acetaminophen plus caffeine but not caffeine alone caused a significant reduction of pain-related cortical potentials beginning 30 minutes after medication.
Caffeine accelerated acetaminophen absorption, indicated by enhanced early AUCs.
In this study, caffeine enhanced and prolonged the analgesic activity of acetaminophen.
Journal of clinical pharmacology  •  2007  |  View Paper
The addition of caffeine disrupted the ability of APAP to coordinate with the heme iron of P450 3A4 and enhanced the rate of oxidation to its toxic metabolite.
Chemical research in toxicology  •  2007  |  View Paper
Interestingly, the metabolism of 3,4-methylenedioxymethylamphetamine and acetaminophen could be stimulated up to 70-fold by the addition of caffeine , a known activator of rat P450 3A2.
Biochemical and biophysical research communications  •  2006  |  View Paper
Caffeine increases the analgesic properties of acetaminophen and therefore it is reasonable to use both substances together in one drug form in stronger pain.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society  •  2017  |  View Paper
The detection limits for the simultaneous determination of paracetamol and caffeine were 4.9 x 10(-7)mol L(-1) and 3.5 x 10(-8)mol L(-1), respectively.
Talanta  •  2009  |  View Paper
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