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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetaminophen
supplement:
Berberine
Research Papers that Mention the Interaction
“Beside, BER induced CYP1A2 activity with increases in AUC0 − t and Cmax of acetaminophen and the Ke and t1/2 of phenacetin after oral administration of phenacetin (p < 0.05) in vivo.”
Enzyme‐inducing effects of berberine on cytochrome P450 1A2 in vitro and in vivo“In mice administered an acetaminophen overdose, a model dependent on inflammasome activation, BRB reduced mortality and ALT (alanine aminotransferase) elevation, and limited the expression of inflammasome components.”
“Post-treatment with three successive oral doses of berberine (4 mg/kg every 6 h) reduced the hepatic damage induced by acetaminophen , while CCl4-induced hepatotoxicity was not modified, suggesting a selective curative effect against acetaminophen.”
Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents.
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