Possible Interaction: Acetaminophen and Arachidonic Acid

“A robust inhibition by acetaminophen and/or meloxicam was observed in arachidonic acid-stimulated platelet aggregation starting at 1× dose.”

“Preincubation with 1 mM acetaminophen for 2 min completely inhibited arachidonic acid- and collagen-stimulated platelet aggregation.”

“The levels of liver tissue fatty acids (saturated, mono and polyunsaturated) such as palmitic acid, stearic acid, oleic acid, linoleic acid, arachidonic acid and linolenic acid monitored by gas chromatography were considerably altered in acetaminophen intoxicated animals when compared with control animals.”

“Using APAP as a probe, it was found that at low concentrations, APAP is converted in a cooxidation reaction with arachidonic acid to a dimer, 4'4"'-dihydroxy-3', 3"'-biacetanilide (bi-APAP), and other polymeric products.”

“It is speculated that the multiple and tissue variable effects that acetaminophen had on arachidonic acid metabolism depend on the inherent cofactors associated with each tissue type.”

“Removal of acetaminophen from the second incubation or addition of arachidonic acid caused increases in both prostaglandin E 2 and cyclic AMP.”

“Abstract Acetamidophenol , which is an antipyretic and analgesic agent devoid of anti-inflammatory properties, suppressed those effects of bradykinin, ATP, slow reacting substance C and arachidonic acid which are usually prevented by non-steroidal anti-inflammatory drugs.”