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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Acetaminophen
supplement:
Apigenin
Research Papers that Mention the Interaction
“A mouse model with acute liver injury was induced by intraperitoneally given acetaminophen 350 mg kg(-1) after oral administration of apigenin 100 and 200 mg kg(-1) for 7 days.”
Protective effect of apigenin on mouse acute liver injury induced by acetaminophen is associated with increment of hepatic glutathione reductase activity.“Meanwhile, API ameliorated the decreased cell viability in L-02 cells incubated by APAP with a dose dependent.”
“Western blotting showed that API promoted APAP-induced autophagy, activated the NRF2 pathway, and inhibited the transcriptional activation of nuclear p65 in the presence of APAP.”
Apigenin Prevents Acetaminophen-Induced Liver Injury by Activating the SIRT1 Pathway
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