Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Acetaminophen and Antioxidants

Research Papers that Mention the Interaction

Studies have demonstrated that antioxidants and anti-inflammatory agents effectively protect against the acute hepatotoxicity induced by APAP overdose.
Mediators of inflammation  •  2014  |  View Paper
Recently, some evidence of the role of certain antioxidant genes in enhancing the association between paracetamol and asthma has been suggested, implying a higher risk in genetically susceptible children.
European journal of anaesthesiology  •  2014  |  View Paper
The combination of MMI with APAP increased the expression of genes involved with oxidative stress and anti-oxidant defense , likely to protect the cells from mitochondrial injury.
Current drug discovery technologies  •  2010  |  View Paper
Overall, APAP exposure altered the expression of Nrf1 and genes related to antioxidant system and disturbed the redox homeostasis of D. magna.
Aquatic toxicology  •  2019  |  View Paper
We found that acetaminophen significantly increased the levels of serum ALP, ALT, AST and MDA, and also significantly reduced the antioxidant factors , CAT, GPX and SOD.
Biotechnic & histochemistry : official publication of the Biological Stain Commission  •  2019  |  View Paper
APAP subsided Nrf2 nuclear accumulation by inhibition of keap1 degradation, thereby reducing the binding of Nrf2 to ARE, leading to the loss of expression of antioxidant proteins such as HO-1, inducing a series of oxidative stress and apoptosis events.
Journal of food biochemistry  •  2019  |  View Paper
When groups treated with acetaminophen , significant increase of liver weight/body weight ratio, liver function enzymes such as alanine aminotransferase (ALT), alkaline phosphatase (ALP) and aspartate aminotransferase (AST) and decrease of antioxidant enzymes such as glutathione (GSH) and superoxide dismutase (SOD) were observed.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2018  |  View Paper
Although PC increases lipid peroxidation and liver enzyme activities, it has led to reduction of antioxidant enzyme activities.
Journal of biochemical and molecular toxicology  •  2017  |  View Paper
Acetaminophen caused significant elevation in the liver functions and lipid peroxidation marker, and decline in the activities of the hepatic antioxidant enzymes.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie  •  2016  |  View Paper
APAP increased MDA formation and lowered the GSH/GSSG ratio and all enzyme activities, especially those of antioxidant enzymes.
Advances in experimental medicine and biology  •  2013  |  View Paper
Show More