Possible Interaction: Acetaminophen and Antioxidants

“Studies have demonstrated that antioxidants and anti-inflammatory agents effectively protect against the acute hepatotoxicity induced by APAP overdose.”

“Recently, some evidence of the role of certain antioxidant genes in enhancing the association between paracetamol and asthma has been suggested, implying a higher risk in genetically susceptible children.”

“The combination of MMI with APAP increased the expression of genes involved with oxidative stress and anti-oxidant defense , likely to protect the cells from mitochondrial injury.”

“Overall, APAP exposure altered the expression of Nrf1 and genes related to antioxidant system and disturbed the redox homeostasis of D. magna.”

“We found that acetaminophen significantly increased the levels of serum ALP, ALT, AST and MDA, and also significantly reduced the antioxidant factors , CAT, GPX and SOD.”

“ APAP subsided Nrf2 nuclear accumulation by inhibition of keap1 degradation, thereby reducing the binding of Nrf2 to ARE, leading to the loss of expression of antioxidant proteins such as HO-1, inducing a series of oxidative stress and apoptosis events.”

“When groups treated with acetaminophen , significant increase of liver weight/body weight ratio, liver function enzymes such as alanine aminotransferase (ALT), alkaline phosphatase (ALP) and aspartate aminotransferase (AST) and decrease of antioxidant enzymes such as glutathione (GSH) and superoxide dismutase (SOD) were observed.”

“Although PC increases lipid peroxidation and liver enzyme activities, it has led to reduction of antioxidant enzyme activities.”

“ Acetaminophen caused significant elevation in the liver functions and lipid peroxidation marker, and decline in the activities of the hepatic antioxidant enzymes.”

“ APAP increased MDA formation and lowered the GSH/GSSG ratio and all enzyme activities, especially those of antioxidant enzymes.”