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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetaminophen
supplement:
Allyl Sulfide
Research Papers that Mention the Interaction
“Diallyl sulfide DAS ) has been shown to prevent xenobiotic (e.g. ethanol, acetaminophen ) induced toxicity and disease (e.g. HIV-1) pathogenesis.”
In vitro evaluation of structural analogs of diallyl sulfide as novel CYP2E1 inhibitors for their protective effect against xenobiotic-induced toxicity and HIV replication.“ Diallyl sulfide blocked APAP arylation of protein, hepatotoxicity, and induction of both hsps.”
Effect of N-acetylcysteine on heat shock protein induction by acetaminophen in mouse liver.“Diallyl sulfide DAS ), a known inhibitor of CYP2E1 and of CYP2A10/2A11 (the rabbit orthologue of mouse CYP2A5), completely eliminated olfactory toxicity of AP in both the Cyp1a2(-/-) and wild-type mouse olfactory mucosa.”
“ DAS pretreatment also decreased the excessive level of TNF-α caused by APAP or CCl4 in serum (p < 0.05).”
Diallyl sulfide treatment protects against acetaminophen-/carbon tetrachloride-induced acute liver injury by inhibiting oxidative stress, inflammation and apoptosis in mice.
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