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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Acetaminophen
supplement:
6-O-Palmitoylascorbic Acid
Research Papers that Mention the Interaction
“Hepatic ascorbate levels also peaked at 4 hours after APAP + AP or AS treatments.”
Effect of ascorbic acid esters on hepatic glutathione levels in mice treated with a hepatotoxic dose of acetaminophen.“The oral administration of [3H(G)]paracetamol (600 mg/kg) resulted in covalent binding to … marked elevation of plasma alanine aminotransferase (ALAT) activity after 24 h. The co-administration of paracetamol … ASCP (1412 mg/kg, equivalent to 600 mg/kg free … metabolites at 2 and 4 h after treatment.”
“Co-administration of the ascorbate esters AP or AS with APAP prevented an increase in liver weight/body weight ratios and hepatic glutathione depletion.”
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