“ HEMA also inhibited significantly the compound 48/80-induced cAMP reduction in RPMC.”
“Moreover, HEMA dose-dependently inhibited mast cell degranulation, histamine release and calcium uptake … RPMC induced by the compound 48/80 or anti-CGG IgE. When HEMA was added, the level of intracellular cAMP in RPMC showed a transient and significant increase (5-fold) compared with that of control cells.”