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Last Updated: 5 months ago

Possible Interaction: 8-Chloro-Cyclic Adenosine Monophosphate and Genistein

Research Papers that Mention the Interaction

Genistein inhibited phosphorylation of the p65 subunit of NF-κB and its interaction with cAMP regulatory element-binding protein-binding protein (CBP)/p300 and TATA-binding protein (TBP).
Mutation research  •  2014  |  View Paper
It was shown that genistein (50 μM) increased basal cAMP and potentiated forskolin-induced cAMP accumulation to the same extent as IBMX (100 μM).
Molecular and Cellular Biochemistry  •  2004  |  View Paper
In the absence of a phosphodiesterase inhibitor, genistein enhanced RLX-stimulated cAMP accumulation in both bioassays.
Molecular human reproduction  •  2001  |  View Paper
Stimulation of cells with a combination of genistein and cAMP also induced Cl- efflux, whereas a combination of pretreatment with 4PBA and a combined stimulation with genistein and cAMP induced an even larger Cl- efflux.
The European respiratory journal  •  2000  |  View Paper
Genistein effectively upregulated cAMP levels and phosphorylation of CREB and TrkB, leading to activation of cAMP/CREB-BDNF-TrkB signaling.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology  •  2017  |  View Paper
The results … of cAMP in the cells treated with … and 15 mug/ml genistein was significantly increased by 9.5%and 11.0%, respectively, 5 min later (P<0.05), then increased … 40.3%, respectively, 10 min later (P<0.01), compared with that of the control group cells.
Sheng li xue bao : [Acta physiologica Sinica]  •  2005  |  View Paper
In the presence of cAMP (> 5 microM), subsequent mucosal, but not serosal, addition of genistein further increased Icl by approximately 16%; in the absence of cytosolic cAMP, genistein had no effect on ICl.
The American journal of physiology  •  1996  |  View Paper
Consistently, genistein improved HG-impaired intracellular cAMP production and PKA activity in HAEC.
The Journal of nutrition  •  2012  |  View Paper
A protein kinase-A inhibitor blocked responses to xenobiotics, while genistein and nonylphenol significantly stimulated cAMP production.
Human reproduction  •  2006  |  View Paper
We show that genistein stimulates intracellular cAMP accumulation in intact bovine aortic endothelial cells and human umbilical vein endothelial cells over an incubation period of 30 min.
Endocrinology  •  2005  |  View Paper
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