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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
5-Hydroxytryptophan
drug:
Zimeldine
Research Papers that Mention the Interaction
“ Zimelidine administration has been … serotonin precursor, 5-hy-droxytryptophan , in the brain tissue of rats following 1-aromatic acid decarboxylase inhibition, and to reduce the concentration of the serotonin … cerebrospinal fluid of patients with depressive illness; these findings are indicative of increased serotonin neurotransmission in the central nervous system.”
Zimelidine: A Review of its Pharmacological Properties and Therapeutic Efficacy in Depressive Illness“The 5-… inhibitors zimelidine (10 mg/kg IP 1.5 h pretest) or alaproclate (20 mg/kg IP 1.5 h pretest) … the ejaculation latency and of the post-ejaculatory interval in male rats treated with a subthreshold dose of 5-hydroxytryptophan (5-HTP) (12.5 … 1 h pretest).”
Further evidence for an inhibitory role of central 5-HT in male rat sexual behavior
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